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A new human B cell line, SJFR17, was established from the peripheral blood lymphocytes of a patient who had had a partial remission of chronic progressive dermatomyositis. The cells have the morphology of typical memory B cells and IgM-positive, cyclin-dependent kinase inhibitor-positive, CD20-negative cells. These cells proliferated very slowly, with a doubling time of more than 6 months, in medium containing alpha- and beta-interferons. This slow proliferation was inhibited by anti-gamma-interferon antibodies. The cells were found to contain a novel, globotriaosylceramide-containing, CD19 and IgD-negative glycosphingolipid (mainly 4-nitrophenyl beta-D-galactopyranosyl ceramide-GlcNAc beta 1—-6Gal beta 1—-4Glc beta 1—-Cer, and some minor ganglio-series gangliosides). These cells proliferated markedly on the addition of a ganglioside mixture, which included GM3, and weakly on the addition of a major ganglioside mixture (GM3, GM2, GD3, GD2, GT1b, and a minor ganglioside). However, neither of these mixtures, except GM3, caused the proliferation of the cells. The cells did not proliferate in the presence of aminoglycosides, such as gentamicin, and they did not respond to lipopolysaccharide or pokeweed mitogen. Southern blot analysis of these cells indicated the presence of a gene rearranged VH-JH. They carried an activated p53 protein, and produced IL-4 in response to staphylococcal enterotoxin B.How nerve roots are compressed in Chiari malformation.
A review of the literature yields conflicting evidence on whether the dorsal cerebellar tonsils are draped upon the cervical spinal cord or whether they are compressed by a buckling or wrapping of the spinal cord. This is probably the most important differential diagnosis that is responsible for great surgical morbidity. In as much as the abdominal contents, intestines and liver are buckling the spinal cord it is logical to

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